Subretinal suspensions of hiPSC-derived retinal pigment epithelium cells form functional monolayers in NOD-SCID mice facilitating treatment of advanced retinal diseases
These findings demonstrate that hiPSC-RPE suspensions can survive and form RPE monolayers with morphological and functional features analogous to those of native human RPE cells in the host retina with a healthy BM. Our study may facilitate the development of cell-based therapies for treatment of advanced retinal degenerations.
Authors
- Suai Zhang
- Xiaojing Song (ORCID: https://orcid.org/0000-0001-9462-0056)
- Ping Xu
- Xiufeng Zhong (ORCID: https://orcid.org/0000-0001-8211-261X)
- Dandan Zheng (ORCID: https://orcid.org/0000-0002-2571-5526)
- Jian Ge (ORCID: https://orcid.org/0000-0001-5165-3368)
- Ke Ye (ORCID: https://orcid.org/0000-0002-9593-9007)
- Yuan Wang (ORCID: https://orcid.org/0000-0002-7981-4829)
- Guanjie Gao
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-08-05
- DOI
- https://doi.org/10.1016/j.reth.2025.06.021
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Basic and Applied Basic Research Foundation of Guangdong Province