Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study
Among individuals with lifetime depression or anxiety from the GLAD Study, the genetic variants that underlie symptom severity largely overlap with those influencing functional impairment. This suggests that self-reported functional impairment, while clinically relevant for diagnosis and treatment outcomes, does not reflect substantial additional genetic liability beyond that captured by symptom-based measures of depression or anxiety.
Authors
- Matthew H. Hotopf (ORCID: https://orcid.org/0000-0002-3980-4466)
- Christopher Rayner (ORCID: https://orcid.org/0000-0003-2950-343X)
- Thalia Catherine Eley (ORCID: https://orcid.org/0000-0001-6458-0700)
- Andrew Mark McIntosh (ORCID: https://orcid.org/0000-0002-0198-4588)
- Gerome D. Breen (ORCID: https://orcid.org/0000-0003-2053-1792)
- Brett N. Adey (ORCID: https://orcid.org/0000-0003-4356-4079)
- Chérie Armour (ORCID: https://orcid.org/0000-0001-7649-3874)
- Yuhao Lin (ORCID: https://orcid.org/0000-0001-6357-5731)
- James Walters (ORCID: https://orcid.org/0000-0002-6980-4053)
- Georgina Krebs (ORCID: https://orcid.org/0000-0002-5353-5645)
- Alicia J. Peel (ORCID: https://orcid.org/0000-0002-6144-5412)
- Katharine A. Rimes (ORCID: https://orcid.org/0000-0003-2634-455X)
- Molly Rose Davies (ORCID: https://orcid.org/0000-0003-3483-9907)
- Jessica Mundy (ORCID: https://orcid.org/0000-0001-5513-8902)
- Ian Jones (ORCID: https://orcid.org/0000-0001-5821-5889)
- Colette R. Hirsch (ORCID: https://orcid.org/0000-0003-3579-2418)
- Daniel J. Smıth (ORCID: https://orcid.org/0000-0002-2267-1951)
- Gursharan Kalsi (ORCID: https://orcid.org/0000-0002-5156-7176)
- David Veale (ORCID: https://orcid.org/0000-0002-1717-4766)
- Joshua E. J. Buckman (ORCID: https://orcid.org/0000-0002-2281-0907)
- Christopher Hübel (ORCID: https://orcid.org/0000-0002-1267-8287)
- Jonathan R. I. Coleman (ORCID: https://orcid.org/0000-0002-6759-0944)
- Megan Skelton (ORCID: https://orcid.org/0000-0002-7619-349X)
- Abigail ter Kuile (ORCID: https://orcid.org/0000-0002-7869-3754)
- Sang Hyuck Lee (ORCID: https://orcid.org/0000-0002-5610-033X)
- Katherine Thompson (ORCID: https://orcid.org/0000-0003-1818-0428)
Institutions
- Queen's University Belfast (GB)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Aarhus University (DK)
- Karolinska Institutet (SE)
- Centre for Mental Health (GB)
- University College London (GB)
- Cardiff University (GB)
- Camden and Islington NHS Foundation Trust (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725101037
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Biogen
- NHS Blood and Transplant
- National Institute for Health and Care Research
- Department of Health and Social Care
- King's College London
- H. Lundbeck A/S
- NIHR BioResource
- NIHR Maudsley Biomedical Research Centre
- Economic and Social Research Council