Chronic Far-UVC (222nm) Light Exposure of SKH-1 Hairless Mice Does Not Cause Detectable Eye Pathology or Visual Deficits
There was no relationship between far-UVC dose and visual acuity, contrast sensitivity, ocular pressure, or corneal neovascularization. Female mice had significantly higher visual acuity and contrast sensitivity. No ocular pathologies were observed, even at 400 mJ/cm<sup>2</sup>, substantially above the recently enacted ACGIH safety threshold of 160 mJ/cm<sup>2</sup> for 222 nm ocular exposures. More sensitive or detailed corneal examinations, longer daily exposures, or higher far-UVC doses, may be useful to define thresholds for human eye safety.
Authors
- David Welch (ORCID: https://orcid.org/0000-0003-2784-496X)
- Norman J. Kleiman (ORCID: https://orcid.org/0000-0002-4725-998X)
- Peter C. Arden (ORCID: https://orcid.org/0000-0003-0228-5532)
- David J. Brenner (ORCID: https://orcid.org/0000-0002-0926-1210)
- Nabil A. Mahmoud
- Maria Jose Talayero Schettino
- Matthew D. Ramey
- Imke T. Folkerts (ORCID: https://orcid.org/0009-0001-1175-4292)
Institutions
- Milken Institute (US)
- State University of New York (US)
- SUNY Downstate Health Sciences University (US)
- George Washington University (US)
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Current Eye Research
- Published
- 2025-08-03
- DOI
- https://doi.org/10.1080/02713683.2025.2524564
- Citations
- 2
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- Boeing