Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2
Our investigation suggests periplocin as a potential agent in the development of ferroptosis-inducing therapies against non-small cell lung cancer.
Authors
- Waleed Yousuf (ORCID: https://orcid.org/0000-0002-9399-1434)
- Yinuo Wang (ORCID: https://orcid.org/0000-0001-5515-9519)
- Zhaoxia Dai (ORCID: https://orcid.org/0009-0005-5404-6893)
- Song Jialiang
- Yingqiu Zhang (ORCID: https://orcid.org/0000-0002-5010-2625)
- Xun Qiu (ORCID: https://orcid.org/0000-0001-5930-1877)
- Zengchun Hu
- Dian Yang (ORCID: https://orcid.org/0000-0003-0303-4049)
- Jiayu Li (ORCID: https://orcid.org/0009-0006-2365-5431)
- Shaoxuan Cheng
- Yuxuan Li (ORCID: https://orcid.org/0000-0002-6265-5948)
- Ziyi Zhang (ORCID: https://orcid.org/0009-0005-9492-3192)
- Peng Wang (ORCID: https://orcid.org/0000-0001-8118-4929)
- Yue Zhu (ORCID: https://orcid.org/0000-0002-3463-6037)
- Shuyan Liu (ORCID: https://orcid.org/0000-0002-5932-4857)
- Jinhao Wang (ORCID: https://orcid.org/0009-0008-7747-1851)
- Mengyuan Dai
- Fengping Yang
Institutions
- Dalian Medical University (CN)
- Suizhou Central Hospital (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s12935-025-03925-5
- Citations
- 2
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province