The contribution of minimally invasive tissue sampling compared to antemortem-derived cause of death determination among inpatient child deaths: the minimally invasive tissue sampling in Malawi study
The addition of MITS to clinical and inpatient research data led to almost all (97%) of cases receiving new and/or refined diagnoses, including microbe identification in infectious conditions. Pathogens not specifically addressed by current clinical guidelines, such as Klebisiella pneumoniae, were commonly identified. Our findings support the utility of MITS to understand CoD even after thorough clinical characterisation of children during hospitalisation.
Authors
- Christopher A. Moxon (ORCID: https://orcid.org/0000-0001-6087-9393)
- Maureen H. Diaz (ORCID: https://orcid.org/0000-0001-7959-9543)
- Charalampos Attipa (ORCID: https://orcid.org/0000-0001-6039-6586)
- Stanley Khoswe
- Robert Bandsma (ORCID: https://orcid.org/0000-0001-6358-4750)
- Isabel Potani (ORCID: https://orcid.org/0000-0002-3494-534X)
- James Alexander Berkley (ORCID: https://orcid.org/0000-0002-1236-849X)
- Daniëlla Brals
- Judd L. Walson (ORCID: https://orcid.org/0000-0003-4836-720X)
- Dennis Chasweka (ORCID: https://orcid.org/0000-0003-4470-5144)
- Wieger P. Voskuijl (ORCID: https://orcid.org/0000-0001-5825-2831)
- Emmie Mbale (ORCID: https://orcid.org/0000-0001-7134-2858)
- Cornelius Huwa
- Donna M. Denno (ORCID: https://orcid.org/0000-0002-5968-9266)
- Steve Kamiza
- Jaume Ordï (ORCID: https://orcid.org/0000-0002-4820-7954)
- Chisomo Eneya
- Sarah Lawrence (ORCID: https://orcid.org/0000-0002-7317-0583)
- Jessica L. Waller
Institutions
- Roslin Institute (GB)
- Johns Hopkins University (US)
- University of Liverpool (GB)
- National Center for Immunization and Respiratory Diseases (US)
- University of Washington (US)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Kamuzu Central Hospital (MW)
- Hospital for Sick Children (CA)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- Wellcome Centre for Molecular Parasitology (GB)
- Emma Kinderziekenhuis (NL)
- Amsterdam Institute for Global Health and Development (NL)
- The Childhood Acute Illness and Nutrition Network (KE)
- Barcelona Institute for Global Health (ES)
- Amsterdam University Medical Centers (NL)
- Kamuzu University of Health Sciences (MW)
- Universitat de Barcelona (ES)
- University of Glasgow (GB)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Global Health
- Published
- 2025-08-04
- DOI
- https://doi.org/10.7189/jogh.15.04210
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- University of Washington
- University of Oxford