Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and <scp>BMI</scp> ‐Corrected <i>Z</i> Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Serum neurofilament light chain Z scores consistently outperformed absolute concentration cutoffs for prognostication of clinical/radiological disease activity and may facilitate individual prediction of treatment response.

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Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2025-08-03
DOI
https://doi.org/10.1002/acn3.70149
Citations
2
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
2.94

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article

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI ‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Sabine Schädelin, Riccardo Galbusera, Lisa Hofer, Marjolaine Uginet et al.
2 citations
Annals of Clinical and Translational Neurology
Multiple Sclerosis Research Studies
2.94
article

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI ‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Sabine Schädelin, Riccardo Galbusera, Lisa Hofer, Marjolaine Uginet, Marcus D’Souza, Eline A.J. Willemse, Björn Tackenberg, Andrew Lung-Tat Chan, Patrice H. Lalive, Alessandro Cagol, Ahmed Abdelhak, Heinz Wiendl, Claudio Gobbi, Jens Kühle, Sofia Sandgren, Ludwig Kappos, Robert Hoepner, Giulio Disanto, Amandine Mathias, Özgür Yaldizli, Klaus Berger, Juan Gómez, Maximilian Einsiedler, Lars G. Hemkens, Chiara Zecca, Renaud Du Pasquier, Marco Hermesdorf, David Leppert, Henrik Zetterberg, Pascal Benkert, Caroline Pot, Fredrik Piehl, Sebastian Finkener, Aleksandra Maleska Maceski, Johanna Oechtering, Cristina Granziera, Lester Melie‐García, Tobias Derfuss, David Brassat, Patrick Roth, Tjalf Ziemssen, Stefanie Müller, Amar Zadic
article en
2 citations

Abstract

Serum neurofilament light chain Z scores consistently outperformed absolute concentration cutoffs for prognostication of clinical/radiological disease activity and may facilitate individual prediction of treatment response.

Annals of Clinical and Translational NeurologyVol. 12(11)
University of Geneva (CH), Roche (Switzerland) (CH), University of Bern (CH), Novartis (Switzerland) (CH), University of Wisconsin–Madison (US), Philipps University of Marburg (DE), University of California, San Francisco (US), University of Basel (CH), University of Zurich (CH), University of St.Gallen (CH), University of Münster (DE), Kantonsspital St. Gallen (CH), University Hospital of Bern (CH), Sahlgrenska University Hospital (SE), University Medical Center Freiburg (DE), University Hospital of Basel (CH), Karolinska Institutet (SE), Sorbonne Université (FR), Laboratory for Biomedical Neurosciences (CH), University Hospital of Zurich (CH), University Hospital of Geneva (CH), Institute for Neurodegenerative Disorders (US), Pitié-Salpêtrière Hospital (FR), UK Dementia Research Institute (GB), Department of Biomedicine Basel (CH), Stockholm Health Care Services (SE), National Hospital for Neurology and Neurosurgery (GB), Kantonsspital Aarau (CH), University Hospital Carl Gustav Carus (DE), University College London (GB), Università della Svizzera italiana (CH), University of Gothenburg (SE), University of Lausanne (CH)
National Science Foundation, Bristol-Myers Squibb, Eli Lilly and Company, Merck, Novartis, Roche, Sanofi, Biogen, Teva Pharmaceutical Industries, Alexion Pharmaceuticals, Celgene, F. Hoffmann-La Roche, Västra Götalandsregionen, CSL Behring, Universität Basel, European Committee for Treatment and Research in Multiple Sclerosis, University of Bern, Merck KGaA, Novocure, International Progressive MS Alliance, Inselspital, Universitätsspital Bern, Multiple Sclerosis Society, European Commission, National Research Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Sahlgrenska Universitetssjukhuset, Göteborgs Universitet, Université de Genève, Université de Lausanne, Centre Hospitalier Universitaire Vaudois, Universität Zürich, Schweizerische Multiple Sklerose Gesellschaft, Universitätsspital Zürich, Servier, Novartis Pharma, Sanofi Genzyme, Sahlgrenska Akademin
Good health and well-being
Openalex Percentile: Top 9%
Multiple Sclerosis Research Studies
2.94
DOIOpen Access PDFOpenAlex
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