Predictors of Quality of Life in Patients With Parkinson’s Disease: A Multicenter Case-control Study

Introduction: Parkinson's disease (PD) is a common neurodegenerative disease whose motor and non-motor complications significantly affect a person's quality of life (QoL).This study aimed to investigate the QoL of these patients using the PD questionnaire (PDQ)-39 and identify the prognostic factors associated with their QoL. Methods:In this case-control study, the QoL of two groups (211 controls and 211 cases) was investigated and compared using the PDQ-39 questionnaire.Prognostic factors associated with QoL were determined using multivariate logistic regression analyses.Results: Several 422 patients with a mean age of 59.813.7 years were included in the study.The mean PDQ-39 score in the case group was significantly higher in all subscales, except for social support, compared to the control group.The mean score of PDQ-39 was significantly higher in the patients with non-deep brain stimulation (DBS) (53.921.1 (than those with DBS (42.2218.1),especially in the sub-scales of mobility, activities of daily living, cognition, and communication.As the stage of the disease increased, the mean PDQ-39 score in these patients increased significantly.The results of the multivariate analysis showed that sex, patient age, smoking, education level, duration of disease, patient stage, and intervention with DBS were significantly related to patients' QoL (P<0.05). Conclusion:This study highlights the significant impact of DBS on PD patients' QoL, especially in sub-scales of mobility, daily activities, emotional well-being, and cognition.Moreover, identifying the main prognostic factors of QoL (sex, age, smoking status, educational level, disease duration, and stage) can lead to avenues for improving the lives of these patients.