Spermatocytic tumor associated with metastases: report of a rare case and literature review

Spermatocytic tumor (ST) is an exceedingly rare testicular neoplasm with non-specific clinical presentations, requiring histopathological confirmation for diagnosis. Radical orchiectomy remains the cornerstone of treatment, achieving favorable outcomes in most cases. However, early metastasis observed in some patients emphasizes the necessity of comprehensive systemic staging at diagnosis and rigorous postoperative surveillance. Current evidence is largely derived from case reports, limiting robust clinical guidance. Herein we present a case of pure testicular ST with synchronous multiple pulmonary metastases managed at Tangdu Hospital. Despite undergoing radical orchiectomy followed by chemotherapy, the patient exhibited disease progression. Additionally, we performed a literature review of published ST cases to summarize its clinicopathological features, treatment paradigms, and prognostic patterns. This study highlights the challenges in managing advanced ST and underscores the need for standardized therapeutic protocols.

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Journal
Frontiers in Pharmacology
Published
2025-08-04
DOI
https://doi.org/10.3389/fphar.2025.1636142
Primary Topic
Testicular diseases and treatments
Type
article
Field-Weighted Citation Impact
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article

Spermatocytic tumor associated with metastases: report of a rare case and literature review

Jianbai Chen, Xiao-Rong Mou, Yanyao Gao, Xiaoping Gao et al.
Frontiers in Pharmacology
Testicular diseases and treatments
article

Spermatocytic tumor associated with metastases: report of a rare case and literature review

Jianbai Chen, Xiao-Rong Mou, Yanyao Gao, Xiaoping Gao, Wei Zhang, Jianxin Qiu, Zhiming Zhang, Zhiyong Nie
article en

Abstract

Spermatocytic tumor (ST) is an exceedingly rare testicular neoplasm with non-specific clinical presentations, requiring histopathological confirmation for diagnosis. Radical orchiectomy remains the cornerstone of treatment, achieving favorable outcomes in most cases. However, early metastasis observed in some patients emphasizes the necessity of comprehensive systemic staging at diagnosis and rigorous postoperative surveillance. Current evidence is largely derived from case reports, limiting robust clinical guidance. Herein we present a case of pure testicular ST with synchronous multiple pulmonary metastases managed at Tangdu Hospital. Despite undergoing radical orchiectomy followed by chemotherapy, the patient exhibited disease progression. Additionally, we performed a literature review of published ST cases to summarize its clinicopathological features, treatment paradigms, and prognostic patterns. This study highlights the challenges in managing advanced ST and underscores the need for standardized therapeutic protocols.

Frontiers in PharmacologyVol. 16
Air Force Medical University (CN)
Good health and well-being
Openalex Percentile: Top 68%
Testicular diseases and treatments
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Spermatocytic tumor associated with metastases: report of a rare case and literature review — Jianbai Chen, Xiao-Rong Mou, et al. · Frontiers in Pharmacology (2025) | TGRS Research Map | TGRS