Empagliflozin attenuates pyroptosis by regulating thioredoxin-NLRP3 inflammasome axis in a high fat cholesterol diet/streptozotocin model of atherosclerosis
EMPA displayed antioxidant and anti-inflammatory effects through attenuating the OS/TXNIP/NLRP3/GSDMD axis in an experimental model of atherosclerosis.
Authors
- Doaa Mohamed Abdel-Wahed (ORCID: https://orcid.org/0009-0006-2826-4472)
- Nevien Hendawy (ORCID: https://orcid.org/0000-0003-0200-1034)
- Sayed El-Sayed
- Sedra Hesham Salaheldin
- Sally A Abuelezz
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- Gulf Medical University (AE)
- Grand Egyptian Museum (EG)
- Universidad de Cádiz (ES)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1093/jpp/rgaf051
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61