Ginkgolide as a Promising Multi-Target Therapeutic for Alzheimer's Disease: Targeting ApoE4 and Beyond
The results demonstrated ginkgolide as a potentially effective multi-target treatment for AD through ApoE4 regulation. It is a better option than other natural chemicals because of its potent binding affinity, stability, and pharmacokinetics. These findings highlight the value of in silico methods in the early stages of drug discovery and the need for additional experimental support before they can be used in clinical settings.
Authors
- Mansoor Alsahag
- Ali Alisaac (ORCID: https://orcid.org/0000-0003-1463-4488)
- Hesham A. Malak (ORCID: https://orcid.org/0000-0001-5101-8348)
- Abdullateef Alshehri (ORCID: https://orcid.org/0009-0003-8467-9611)
- Mohammad H. Alyami (ORCID: https://orcid.org/0000-0003-2731-1071)
- Saba Beigh
- Sajad Ahmad Dar (ORCID: https://orcid.org/0000-0003-2499-8701)
- Soma Ajlan
Institutions
- Umm al-Qura University (SA)
- Menoufia University Hospitals (EG)
- Najran University (SA)
- Al Baha University (SA)
- Menoufia University (EG)
- Jazan University (SA)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-08-04
- DOI
- https://doi.org/10.2174/0113816128386836250723134001
- Citations
- 1
- Primary Topic
- Ginkgo biloba and Cashew Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.38