Synthesis, Antiproliferative Activity, ADME Profiling, and Docking Studies of Novel 1, 2, 3-Triazole Derivatives of 2-Amino and 2-Mercaptobenzoxazole
This study outlines a viable method for the synthesis of novel 1,2,3-triazole derivatives of 2-aminobenzoxazole and 2-mercaptobenzoxazole. Compounds 3 and 29 demonstrate promising antiproliferative activity and pharmacokinetic potential, supporting their further development as anticancer candidates.
Authors
- Tatjana Gazivoda Kraljević (ORCID: https://orcid.org/0000-0002-0543-5391)
- Vesna Rastija (ORCID: https://orcid.org/0000-0001-9542-4022)
- Robert Ostrički
- Leentje Persoons (ORCID: https://orcid.org/0000-0002-7898-0868)
- Dirk Daelemans (ORCID: https://orcid.org/0000-0001-7092-1153)
- Anja Rakas
Institutions
- University of Zagreb (HR)
- Rega Institute for Medical Research (BE)
- University North (HR)
- University of Osijek (HR)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-08-04
- DOI
- https://doi.org/10.2174/0109298673393777250714045359
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00