Preliminary Study on GZMA- and GSDMB-Associated Pyroptosis and CD8+ T Cell-Mediated Immune Evasion in Skin Cutaneous Melanoma
Based on the pyroptosis features in SKCM, this study found that blocking GZMA proteins in CD8+ T cells within melanocytes may be the underlying pathogenesis for tumor immune escape in cancer.
Authors
- Zhiliang Huang (ORCID: https://orcid.org/0009-0008-1264-9727)
- Wen Ce Sun (ORCID: https://orcid.org/0000-0003-4316-5350)
- Jingli Xu (ORCID: https://orcid.org/0000-0003-1594-6221)
- Jianqin Chen (ORCID: https://orcid.org/0000-0003-0310-4844)
- Fengfeng Xie
- Wenfang Xie
- Jing Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Quzhou City People's Hospital (CN)
- First People’s Hospital of Jingmen (CN)
- Central People's Hospital of Zhanjiang (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- The 180th Hospital of PLA (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Zhanjiang Experimental Station (CN)
- Xiamen Chang Gung Hospital (CN)
- Traditional Chinese Medicine Bureau of Guangdong Province (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-08-04
- DOI
- https://doi.org/10.2174/0115680266416033250731102049
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00