Loss of β‐cell identity in human islets treated with glibenclamide
Chronic exposure of human islets to glibenclamide induced the loss of β-cell identity, which was mediated by ER stress, impaired β-cell function, and increased β-cell apoptosis. These negative effects of glibenclamide may contribute to the secondary failure of sulfonylureas and accelerate the decline of functional β-cell mass in patients with type 2 diabetes.
Authors
- Sandra Marín‐Cañas (ORCID: https://orcid.org/0000-0003-3612-5908)
- Noèlia Téllez (ORCID: https://orcid.org/0000-0001-7879-3256)
- Kevin Rivera (ORCID: https://orcid.org/0000-0002-3078-012X)
- Eduard Montanya (ORCID: https://orcid.org/0000-0003-2518-9076)
- Montserrat Nacher (ORCID: https://orcid.org/0000-0002-8458-9275)
- Elisabet Estil·les (ORCID: https://orcid.org/0000-0002-3100-4325)
- Claudia Fernández (ORCID: https://orcid.org/0000-0002-6203-9723)
- Patricia San José (ORCID: https://orcid.org/0000-0002-1884-3554)
- María Sorribas (ORCID: https://orcid.org/0000-0003-2354-3860)
- Gabriel Moreno‐González (ORCID: https://orcid.org/0000-0003-3281-1126)
Institutions
- Bellvitge University Hospital (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1111/dom.16632
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Universitat de Barcelona
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- European Regional Development Fund