RENOPROTECTIVE AND HEPATOPROTECTECTIVE POTENTIALS OF L-ARGININE AND GLUTAMATE ON STREPTOZOTOCIN INDUCED DIABETIC ALBINO RATS

Diabetes mellitus is one of the most common metabolic disorders globally. L-arginine and glutamate have promising beneficial effects against metabolic disorders. Renoprotective and Hepatoprotectective potentials of L-Arginine and Glutamate on Streptozotocin Induced Diabetic albino rats. A total of 73 adult albino rats were used. Out of this, 13 rats were used for LD50 study while 60 rats were used for the proper study. They were grouped into 6, Group 1 served as Normal control, Group 2-6 were diabetic rats induced with streptozotocin (120mg/kg bwt) served as Diabetic control (administered only 0.2 ml normal saline daily). Groups 3, 4, 5 and 6 rats were diabetic rats given Glibenclamide (3 mg/kg bwt), L-Arginine (50 mg/kg bwt), Glutamate (50 mg/kg bwt), L-Arginine and Glutamate (50 mg/kg bwt), respectively for 30 days. After the treatment period, the animals were sacrificed; blood sample collected, and serum separated for determination of liver function status, lipid profile, kidney function markers, There were significant (P<0.05) decrease in the activities of AST and ALT when the treatment groups were compared to the diabetic group, the L-arginine group showed the lowest AST activity followed by the Glibenclamide control group then the group co-treated with L-arginine and glutamate. The effects of L-arginine and glutamate on renal function; urea, creatinine showed a significant decrease (p<0.05) in the l-arginine and glutamate treated group when compared to the diabetic group, and in sodium, potassium and chloride levels when compared to the drug control group. It could be concluded that L-arginine and glutamate have also showed reno-protective and hepato-protective potentials.