Parental Education Predicts Longitudinal IQ Trajectories in 22q11.2 Deletion Syndrome: A Three‐Cohort European Study
Parental education emerged as a key predictor of IQ, suggesting that socioeconomic factors contribute to cognitive performance variability in individuals with 22q11DS. Even in high-penetrance genetic variants, such as the 22q11.2 deletion, environmental factors and gene-environment interactions may make significant contributions to the severity of phenotypes.
Authors
- Yelyzaveta Snihirova (ORCID: https://orcid.org/0000-0003-1844-1384)
- Thérèse van Amelsvoort (ORCID: https://orcid.org/0000-0003-1135-5133)
- David E.J. Linden (ORCID: https://orcid.org/0000-0002-5638-9292)
- Claudia Vingerhoets (ORCID: https://orcid.org/0000-0001-7790-5041)
- Janet Harwood (ORCID: https://orcid.org/0000-0002-3225-0069)
- Dennis van der Meer (ORCID: https://orcid.org/0000-0002-0466-386X)
- Ann Swillen (ORCID: https://orcid.org/0000-0003-4258-4537)
- Marianne B. M. van den Bree (ORCID: https://orcid.org/0000-0002-4426-3254)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Maastricht University (NL)
- Centre For Human Genetics (IN)
- Center for Human Genetics (US)
- 's Heeren Loo (NL)
- Cardiff University (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Intellectual Disability Research
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1111/jir.70025
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Medical Research Council
- National Institute of Mental Health