Clozapine‐associated pneumonia

Despite clozapine's recognized efficacy for patients with treatment‐resistant schizophrenia, most clinicians are aware that it can cause such serious adverse effects as agranulocytosis, seizures, myocarditis, obstipation, and orthostatic hypotension. Less well known are clinical reports and research suggesting an increased risk of pneumonia (Cepaityte et al., 2021). Other than dosage reduction, there has been little guidance on prevention of clozapine‐associated pneumonia, or whether clozapine can be reinstated after its resolution.