Changes in Cerebrovascular Resistance with Hypertension and Telmisartan Treatment in Tg2576 mice

Angiotensin receptor blockers (ARBs) may slow hypertension-induced cerebrovascular changes in Alzheimer’s disease (AD). We measured cerebrovascular resistance (CVR) during hypertension and ARB treatment in AD mice. Hypertension increased CVR with minimal ARB treatment effects.

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Published
2025-01-01
DOI
https://doi.org/10.1364/brain.2025.bw2b.3
Primary Topic
Optical Imaging and Spectroscopy Techniques
Type
article
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article

Changes in Cerebrovascular Resistance with Hypertension and Telmisartan Treatment in Tg2576 mice

Mark Fisher, David H. Cribbs, Christian Crouzet, Kim N. Green et al.
Optical Imaging and Spectroscopy Techniques
article

Changes in Cerebrovascular Resistance with Hypertension and Telmisartan Treatment in Tg2576 mice

Mark Fisher, David H. Cribbs, Christian Crouzet, Kim N. Green, Noé Rubén Chávez, Danny F. Xie, Natalie M. Johnson, Bernard Choi, Jihua Liu, Han Liu, Thinh Phan
article en

Abstract

Angiotensin receptor blockers (ARBs) may slow hypertension-induced cerebrovascular changes in Alzheimer’s disease (AD). We measured cerebrovascular resistance (CVR) during hypertension and ARB treatment in AD mice. Hypertension increased CVR with minimal ARB treatment effects.

University of California, Irvine (US), Beckman Laser Institute and Medical Clinic (US)
Openalex Percentile: Top 72%
Optical Imaging and Spectroscopy Techniques
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