Skeletal editing of pyridines to aryldialdehydes
Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.
Authors
- Zhishan Su (ORCID: https://orcid.org/0000-0001-5168-3823)
- Weichao Xue (ORCID: https://orcid.org/0000-0002-8376-9485)
- Weidong Jiang (ORCID: https://orcid.org/0000-0003-1775-6456)
- Xueli Zheng (ORCID: https://orcid.org/0000-0001-8394-0310)
- Jiangui Zhao
- Jiaqi Xu (ORCID: https://orcid.org/0000-0002-2774-5016)
- Shaoyun Huang (ORCID: https://orcid.org/0000-0002-2222-3999)
- Ruixiang Li (ORCID: https://orcid.org/0000-0003-2358-1226)
- Haiyan Fu (ORCID: https://orcid.org/0000-0002-7185-2062)
- Meixin Yan
- Hua Chen (ORCID: https://orcid.org/0000-0003-4248-8019)
- Shun Li (ORCID: https://orcid.org/0000-0001-8601-2261)
- Dexi Yang
- Cong Lv (ORCID: https://orcid.org/0009-0007-3225-3378)
- Yonglin Shi
Institutions
- Sichuan University (CN)
- Leshan Normal University (CN)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1038/s41467-025-62627-8
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Sichuan University