Tetrahydroxylated bile acids prevents malignant progression of Barret esophagus <i>in vitro</i> by inhibiting the interleukin-1β-nuclear factor kappa-B pathway
Our data indicates that the hydrophilic bile acid THBA can counteract the cytotoxic and proinflammatory effect of hydrophobic DCA and prevent the malignant progression of BE by inhibiting the IL-1β-NF-κB pathway.
Authors
- Anatolii Mamchur (ORCID: https://orcid.org/0000-0001-5569-7579)
- Shane P. Duggan (ORCID: https://orcid.org/0000-0002-5897-2203)
- Victor Ling (ORCID: https://orcid.org/0000-0002-8279-0645)
- Zu‐Hua Gao (ORCID: https://orcid.org/0000-0001-7232-0933)
- Hui Xue (ORCID: https://orcid.org/0000-0002-7970-8647)
- Yuzhuo Z. Wang (ORCID: https://orcid.org/0000-0002-9749-8591)
- Zhenwei Ma
- Dermot Kelleher
- Xiaojia Niu
Institutions
- University of British Columbia Hospital (CA)
- University of British Columbia (CA)
- Spinal Cord Injury BC (CA)
- Vancouver General Hospital (CA)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-08-05
- DOI
- https://doi.org/10.3748/wjg.v31.i29.107066
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00