Flotillin-1 promotes the progression of hepatocellular carcinoma by activating TFE3-mediated Golgi stress response <i>via</i> inhibition of mTORC1/2
FLOT1 recruits and inhibits mechanistic target of rapamycin complex 1/2, causing dephosphorylation and TFE3 nuclear translocation, thereby activating the Golgi stress response and further promoting the proliferation, migration, and invasion capabilities of HCC cells. These results underscore the potential of FLOT1 as a promising therapeutic target for HCC.
Authors
- Ya-Lun Chen
- Chunxue Bai
- Shanhong Tang (ORCID: https://orcid.org/0000-0001-6652-2942)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-9463-3241)
- Hong-Li Xue
- Shan Jin (ORCID: https://orcid.org/0000-0002-2343-9134)
- Shumei Zheng
Institutions
- Chengdu Military General Hospital (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-08-05
- DOI
- https://doi.org/10.3748/wjg.v31.i29.106895
- Citations
- 2
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 2.30