Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration
Gradual DNAm changes were found to align with progression of MASLD and EAA, with EAA a potential nonbiased quantitative biomarker for MASLD. Integrative analysis highlighted potential new therapeutic transcription factor targets, with special emphasis on AEBP1 and emerging nuclear receptors including CAR(NR1I3), MR(NR3C2), GR(NR3C1), and ESRRG, underscoring the potential of epigenetic redox-metabolic therapies for MASLD.
Authors
- Guy Van Camp (ORCID: https://orcid.org/0000-0001-5105-9000)
- Wim Vanden Berghe (ORCID: https://orcid.org/0000-0003-0161-7355)
- Erik Fransén (ORCID: https://orcid.org/0000-0001-7785-4790)
- Wim Van Hul (ORCID: https://orcid.org/0000-0002-5065-7858)
- Evelien Van Dijck (ORCID: https://orcid.org/0000-0001-9597-0373)
- An Verrijken (ORCID: https://orcid.org/0000-0003-4098-8837)
- Steven Timmermans (ORCID: https://orcid.org/0000-0002-5152-9620)
- Emilie Logie (ORCID: https://orcid.org/0000-0003-1053-2409)
- Ligia Mateiu (ORCID: https://orcid.org/0000-0002-2655-3581)
- Sven Francque (ORCID: https://orcid.org/0000-0002-7527-4714)
- Joe Ibrahim (ORCID: https://orcid.org/0000-0001-9728-5273)
- Steven Van Laere (ORCID: https://orcid.org/0000-0002-2640-0040)
- Timothy James Kendall (ORCID: https://orcid.org/0000-0002-4174-2786)
- Jonathan Andrew Fallowfield (ORCID: https://orcid.org/0000-0002-5741-1471)
- Claude Libert (ORCID: https://orcid.org/0000-0001-6408-036X)
- Luc Van Gaal
Institutions
- University of Antwerp (BE)
- Vlaams Instituut voor Biotechnologie (BE)
- Ghent University (BE)
- Antwerp University Hospital (BE)
- VIB-UGent Center for Inflammation Research (BE)
- Centre for Inflammation Research (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13148-025-01945-6
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- European Commission
- Fonds Wetenschappelijk Onderzoek
- Universiteit Antwerpen
- Vlaamse regering
- Innovate UK