Synthesis of a Water-Soluble BODIPY for Targeting and Assessing the Function of Endoplasmic Reticulum
We report here on a straightforward methodology to synthesize a new water-soluble fluorescent probe <b>Tris-BODIPY-OH 1</b> that contains three pH-independent hydrophilic arms. This probe has been prepared by exploiting a synthetic strategy that includes as a key step the combination of a Cu-(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and a Sonogashira cross-coupling in a sequential one-pot approach. <b>Tris-BODIPY-OH 1</b> provides a significant advancement in the field by expanding the BODIPY toolbox with a biocompatible water-soluble probe, which can be used to specifically label and assess the function of the endoplasmic reticulum.
Authors
- Giacomo Biagiotti (ORCID: https://orcid.org/0000-0002-2910-9849)
- Stefano Cicchi (ORCID: https://orcid.org/0000-0002-4913-6414)
- Stéphane Bodin (ORCID: https://orcid.org/0000-0003-0926-403X)
- Andrei Turtoï (ORCID: https://orcid.org/0000-0003-3813-6635)
- Jacopo Tricomi (ORCID: https://orcid.org/0000-0002-7194-5728)
- Tommy Chastel
- Iztok Urbančič (ORCID: https://orcid.org/0000-0003-3603-6585)
- Hana Kokot (ORCID: https://orcid.org/0000-0001-8569-2816)
- Barbara Richichi (ORCID: https://orcid.org/0000-0001-7093-9513)
- Ernesto G. Occhiato (ORCID: https://orcid.org/0000-0003-2187-2409)
- Serena Filiberti (ORCID: https://orcid.org/0000-0001-9795-2638)
- Francesca Mancusi
- Maja Žežlina
- Layal Rajeh
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Gunma University (JP)
- Université de Montpellier (FR)
- Jožef Stefan Institute (SI)
- Brescia University (US)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Angiogenesis and Cancer Microenvironment Laboratory (FR)
- University of Florence (IT)
- University of Brescia (IT)
Publication Details
- Journal
- ACS Bio & Med Chem Au
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1021/acsbiomedchemau.5c00142
- Citations
- 2
- Primary Topic
- Luminescence and Fluorescent Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- Javna Agencija za Raziskovalno Dejavnost RS