An Expedient Approach for the Synthesis of TAM and MET Receptor Kinase Inhibitor’s Core (<i>R</i>)-2-((4-(4-Amino-2-fluorophenoxy)-1-(4-methoxybenzyl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-3-yl)amino)propan-1-ol

A scalable synthetic route to the kinase inhibitor's core (R)-2-((4-(4-amino-2-fluorophenoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)propan-1-ol targeting TAM and MET kinases is presented. A selective nucleophilic aromatic substitution (SNAr) reaction was developed as the key transformation along with a Cu-catalyzed C–N coupling reaction. This route comprises fewer steps (four steps) compared to the six-step sequence previously reported in the literature, delivering significantly improved overall yield.