FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization
Our findings suggest that FTO-mediated the instability of RASGRF1 mRNA diminishes THCA-related macrophage M2 polarization and THCA progression. Anti-RASGRF1 strategies may be useful for the treatment of THCA.
Authors
- Zongyu Li
- Fangshi Xu (ORCID: https://orcid.org/0000-0002-2282-4743)
- Hao Guan (ORCID: https://orcid.org/0000-0002-5132-4078)
- Jiancang Ma (ORCID: https://orcid.org/0009-0000-1112-8761)
- Gang Cao (ORCID: https://orcid.org/0000-0002-7491-5022)
- Jingyue Lai (ORCID: https://orcid.org/0009-0009-5488-8619)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1007/s10565-025-10073-z
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81