Lactiplantibacillus plantarum attenuate gossypol-induced hepatic lipotoxicity by altering intestinal microbiota for enriching microbial tryptophan metabolites in Nile tilapia (Oreochromis niloticus)
The gut microbiota-derived tryptophan metabolites (IPA and IAA) alleviated FFAs induced lipotoxic liver injury by activating Ahr, which promoted P53 ubiquitination, leading to the enhanced FFAs esterification. Our findings demonstrated that gut microbial metabolites alleviated lipotoxicity by promoting the esterification of FFAs in the liver, offering new insights into the study of probiotics and microbial tryptophan metabolites in fatty liver disease. Video Abstract.
Authors
- Samwel Mchele Limbu (ORCID: https://orcid.org/0000-0001-6063-2745)
- Nannan Zhou (ORCID: https://orcid.org/0000-0002-3427-9033)
- Zhen‐Yu Du (ORCID: https://orcid.org/0000-0001-6581-5313)
- Jorge Galindo‐Villegas (ORCID: https://orcid.org/0000-0002-4250-2477)
- Jing Yang (ORCID: https://orcid.org/0000-0003-1221-7429)
- Fei-Fei Ding
- Mei‐Ling Zhang (ORCID: https://orcid.org/0000-0003-2689-8720)
- Yue-Jian Mao
Institutions
- University of Dar es Salaam (TZ)
- Dar es Salaam Institute of Technology (TZ)
- Nord University (NO)
- Inner Mongolia Electric Power (China) (CN)
- Inner Mongolia Electric Power Survey & Design Institute (China) (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s40168-025-02172-0
- Citations
- 5
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.97
Funders
- National Natural Science Foundation of China
- East China Normal University
- National Key Research and Development Program of China