Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1
These findings demonstrate that enhancing bisecting GlcNAc modification in BC cells promotes PD-L1 degradation and inhibits its binding to PD-1, thereby boosting CD8<sup>+</sup> T cell-mediated cytotoxicity, providing a promising strategy for immune modulation in BC therapy.
Authors
- Xueting Ren (ORCID: https://orcid.org/0000-0002-9437-1560)
- Shuai Lin (ORCID: https://orcid.org/0000-0002-4089-5721)
- Jinpeng Wu (ORCID: https://orcid.org/0009-0009-8783-1723)
- Huafeng Kang (ORCID: https://orcid.org/0000-0002-0379-530X)
- Zengqi Tan (ORCID: https://orcid.org/0000-0002-2268-6248)
- Feng Guan (ORCID: https://orcid.org/0000-0002-6251-2592)
- Xiang Li (ORCID: https://orcid.org/0000-0002-5147-8368)
- Jing Li (ORCID: https://orcid.org/0000-0002-3977-1641)
- Meng Wang (ORCID: https://orcid.org/0000-0001-5090-6239)
- Xiaobin Ma
- Zhen Zhai (ORCID: https://orcid.org/0000-0002-8471-6270)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s40164-025-00693-w
- Citations
- 2
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.59