Differential effects of β-blockers nebivolol and metoprolol on mitochondrial biogenesis and antioxidant defense in angiotensin II-induced pathology in H9c2 cardiomyoblasts
In conclusion, both nebivolol and metoprolol effectively reduce oxidative stress and expression of proinflammatory genes in response to Ang II. However, nebivolol provides increased protection by restoring the antioxidant defense system and mitochondrial functions, highlighting its potential therapeutic advantage in Ang II-induced cardiac pathology.
Authors
- Assim A. Alfadda (ORCID: https://orcid.org/0000-0002-4792-5188)
- Arwa Bazighifan (ORCID: https://orcid.org/0000-0003-1931-319X)
- Rukhsana Gul (ORCID: https://orcid.org/0000-0003-0454-864X)
- Shahid Nawaz (ORCID: https://orcid.org/0009-0003-0323-7388)
Institutions
- King Saud University (SA)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s40360-025-00970-8
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- King Saud University
- King Abdulaziz City for Science and Technology
- National Plan for Science, Technology and Innovation