Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions
Co-administration of nobiletin with THC increased its systemic exposure and enhanced its cytotoxicity to breast cancer. The inhibited activity of CYP1A1 was considered the underlying mechanism of their interaction.
Authors
- Hongming Song (ORCID: https://orcid.org/0000-0002-1282-6016)
- Zhaohe Niu
- Haibo Wang (ORCID: https://orcid.org/0009-0003-4444-7293)
- Xingang Wang (ORCID: https://orcid.org/0000-0002-7522-7782)
- Xiangping Liu (ORCID: https://orcid.org/0000-0001-6554-8411)
- Fengqin Gao
- Weihong Cao
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1007/s12672-025-03229-0
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00