Microbial profiling of community-acquired pneumonia in patients with and without chronic obstructive pulmonary disease: a comprehensive molecular diagnostics study
Although overall microbial detection rates were comparable between groups, P. aeruginosa was disproportionately prevalent in high-risk COPD individuals. While most COPD patients with pneumonia can be managed with standard empirical antibiotics, empirical coverage for P. aeruginosa should be considered for selected high-risk patients. Prospective studies are warranted to evaluate targeted P. aeruginosa coverage to optimize antibiotic stewardship and improve outcomes.
Authors
- Dagfinn Lunde Markussen (ORCID: https://orcid.org/0000-0003-3504-8859)
- Sondre Serigstad (ORCID: https://orcid.org/0000-0002-2582-8328)
- Christian Ritz (ORCID: https://orcid.org/0000-0002-5095-0624)
- Paul Christoffer Lindemann (ORCID: https://orcid.org/0000-0002-7457-5902)
- Harleen M. S. Grewal
- Synne Jenum (ORCID: https://orcid.org/0000-0001-8187-775X)
Institutions
- Oslo University Hospital (NO)
- University of Southern Denmark (DK)
- Haukeland University Hospital (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Pneumonia
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s41479-025-00172-0
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Trond Mohn stiftelse
- Universitetet i Bergen
- Norges Forskningsråd
- Haukeland Universitetssjukehus