A randomized controlled trial on the effect of hydroxychloroquine in mild Graves’ orbitopathy (GO-HCQ): study protocol
This RCT will elucidate the clinical benefits of oral HCQ in patients with mild GO, assessing ophthalmic outcomes, quality of life, disease activity, and thyroid autoantibodies. In addition, data obtained from orbital CT measurements will provide valuable insights into subtle changes in orbital fat and extra-ocular muscle volumes, potentially offering an objective tool for monitoring GO progression. TRIAL REGISTRATION {2A, 2B}: ClinicalTrials.gov NCT05126147. Registered on November 2021. https://clinicaltrials.gov/study/NCT05126147 . All items from the World Health Organization (WHO) Trial Registration Data Set are addressed within the relevant sections of this protocol.
Authors
- Chung-Yi Yang
- Wan-Chen Wu (ORCID: https://orcid.org/0000-0002-2731-5331)
- Shyang‐Rong Shih (ORCID: https://orcid.org/0000-0001-7424-1358)
- Chia‐Hung Lin (ORCID: https://orcid.org/0000-0001-8995-7420)
- Chih-Yuan Wang (ORCID: https://orcid.org/0000-0001-6594-406X)
- Yi‐Hsuan Wei (ORCID: https://orcid.org/0000-0002-2087-9855)
- Hung‐Yuan Li (ORCID: https://orcid.org/0000-0001-9644-2855)
- Jin‐Ying Lu (ORCID: https://orcid.org/0000-0002-6125-2274)
- Chung‐Wei Lee (ORCID: https://orcid.org/0000-0002-4165-847X)
- Chin‐Hao Chang
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- I-Shou University (TW)
Publication Details
- Journal
- Trials
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13063-025-09002-6
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council
- National Center of Excellence for Clinical Trial and Research