APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells
APJ signaling is critical for balancing VESC self-renewal and differentiation. APJ deficiency disrupts this balance, leading to impaired vascular regeneration in the liver due to delayed VESC differentiation. This defect is associated with altered transcriptional regulation, favoring a proliferative, undifferentiated state and extracellular matrix changes that weaken structural integrity. These findings highlight the apelin/APJ pathway as a potential therapeutic target to enhance vascular regeneration in regenerative medicine.
Authors
- Man Wang (ORCID: https://orcid.org/0000-0002-5681-990X)
- Fitriana Nur Rahmawati
- Fumitaka Muramatsu (ORCID: https://orcid.org/0000-0001-5899-3111)
- Zeynep Bal (ORCID: https://orcid.org/0000-0003-1563-5036)
- Nobuyuki Takakura (ORCID: https://orcid.org/0000-0003-0397-8605)
- Wenting Li (ORCID: https://orcid.org/0000-0001-5288-8310)
- Weizhen Jia
- Faya Nuralda Sitompul
Institutions
- The University of Osaka (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s41232-025-00389-y
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- Research Institute for Microbial Diseases, Osaka University