Assessing the role of endothelium-protective drugs: Functional and molecular insights into chronic thromboembolic pulmonary hypertension derived endothelial cells
Therapeutic approaches targeting endothelial dysfunction and the NO/sGC pathway in CTEPH partially restore endothelial function, highlighting the dual action of Riociguat and Sildenafil, stimulating sGC while exerting upstream effects by enhancing eNOS signaling. These findings underscore the importance of targeted pharmacological approaches to improve patient outcomes.
Authors
- Joan Albert Barberà (ORCID: https://orcid.org/0000-0003-1469-4990)
- Olga Tura-Ceide (ORCID: https://orcid.org/0000-0003-4334-9790)
- Ana M. Ramírez
- Shuai Yuan (ORCID: https://orcid.org/0000-0002-9590-6555)
- Víctor I. Peinado (ORCID: https://orcid.org/0000-0001-9793-9433)
- Neus Solanes
- Isabel Blanco (ORCID: https://orcid.org/0000-0001-9452-3432)
- Manuel Castellà (ORCID: https://orcid.org/0000-0001-9274-2121)
- Jeisson Osorio (ORCID: https://orcid.org/0000-0003-3808-808X)
- Adam C. Straub (ORCID: https://orcid.org/0000-0003-0542-9466)
- Paula Poyatos (ORCID: https://orcid.org/0000-0003-0200-9087)
- Montserrat Rigol (ORCID: https://orcid.org/0000-0002-3763-1282)
Institutions
- University of Pittsburgh (US)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Clínic de Barcelona (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Medical Research Network (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1016/j.biopha.2025.118425
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00