Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer
An enhancer mechanism mediated by a noncoding variant drives prostate cancer risk by regulating tumor suppressor expression and ferroptosis while conferring susceptibility to the potential of genotype-based precision therapeutic approaches.
Authors
- Gong‐Hong Wei (ORCID: https://orcid.org/0000-0001-6546-9334)
- Jianbo Tian (ORCID: https://orcid.org/0000-0001-9493-694X)
- Meng Jin (ORCID: https://orcid.org/0000-0003-2009-916X)
- Zhihua Wang (ORCID: https://orcid.org/0000-0002-5155-1457)
- Zheng Chao
- Baojun Wang (ORCID: https://orcid.org/0000-0003-4036-9470)
- Zequn Lu (ORCID: https://orcid.org/0000-0003-3165-9097)
- Tengfei Li (ORCID: https://orcid.org/0009-0004-4435-7527)
- Zezhong Xiong (ORCID: https://orcid.org/0000-0003-3407-8247)
- David Horne (ORCID: https://orcid.org/0000-0002-9300-1082)
- Jing Li (ORCID: https://orcid.org/0000-0002-7973-3930)
- Yanan Wang (ORCID: https://orcid.org/0000-0001-6823-0775)
- Qin Zhang (ORCID: https://orcid.org/0000-0003-3467-4241)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-6908-6768)
- Chunyu Zhang
- Sheng Ma (ORCID: https://orcid.org/0009-0000-8037-1474)
- Le Li (ORCID: https://orcid.org/0000-0002-5142-9742)
- Mengyao Xu
- Ruiyun Zhang
- Xu Gao (ORCID: https://orcid.org/0000-0003-1521-9948)
- Yue Ge (ORCID: https://orcid.org/0009-0006-6426-6344)
- Hao Peng (ORCID: https://orcid.org/0009-0003-3433-8181)
- Yuan Gao (ORCID: https://orcid.org/0009-0005-8953-4643)
- Yuzheng Peng
- Zirui Xi
- Junbiao Zhang (ORCID: https://orcid.org/0000-0003-2713-1185)
Institutions
- Northwestern University (US)
- City Of Hope National Medical Center (US)
- Shanghai Medical College of Fudan University (CN)
- Central South University (CN)
- Second Military Medical University (CN)
- Xiamen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese PLA General Hospital (CN)
- Wuhan University (CN)
- City of Hope (US)
- Changhai Hospital (CN)
- Suzhou Institute of Systems Medicine (CN)
- Xiangya Hospital Central South University (CN)
- Tongji Hospital (CN)
- Beckman Research Institute
- Huazhong University of Science and Technology (CN)
- Xiamen University of Technology (CN)
- University of Oulu (FI)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1158/0008-5472.can-24-5018
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56