Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration
Treatment with lipid nanoparticle-encapsulated mRNA encoding tumor-specific toxin proteins reduces tumor growth and activates antitumor immunity, providing an alternative approach for treating tumors that are resistant or unresponsive to immunotherapy.
Authors
- Jing Wang (ORCID: https://orcid.org/0000-0001-5479-5863)
- Shan Cen (ORCID: https://orcid.org/0000-0003-3358-0411)
- Meichen Liu
- Yijie Dong
- Ling Ma (ORCID: https://orcid.org/0000-0001-6479-766X)
- Rui Zhou (ORCID: https://orcid.org/0009-0007-2491-114X)
- Tingting Zhang
- Weiguo Zhang (ORCID: https://orcid.org/0009-0004-3178-5901)
- Tianming Qi
- Lu Han (ORCID: https://orcid.org/0009-0007-5911-9128)
Institutions
- Universidade Estadual de Londrina (BR)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kai Biotech (South Korea) (KR)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3914
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.81