Spatial Multiomics Defines a Shared Tumor Infiltrative Signature at the Resection Margin in High-Grade Gliomas
Characterization of infiltrating tumor-margin cells across human high-grade gliomas advances the understanding of residual disease biology at the surgical margin, identifies mechanisms of therapy resistance and recurrence, and elucidates targetable molecular features.
Authors
- Sanjana Shroff (ORCID: https://orcid.org/0000-0003-2839-0322)
- Susana Isabel Ramos (ORCID: https://orcid.org/0000-0003-2886-6781)
- Raymund L. Yong (ORCID: https://orcid.org/0000-0002-7585-4153)
- Kristin G. Beaumont (ORCID: https://orcid.org/0000-0003-3075-9977)
- Elena Zaslavsky
- Balagopal Pai (ORCID: https://orcid.org/0000-0003-3196-055X)
- Nadejda M. Tsankova (ORCID: https://orcid.org/0000-0002-5333-312X)
- Jessica Tomé-García (ORCID: https://orcid.org/0000-0003-0554-8676)
- Lakshmi Shree Kulumani Mahadevan (ORCID: https://orcid.org/0000-0003-4701-252X)
- German Nudelman
- Tanvi Joshi (ORCID: https://orcid.org/0000-0001-7436-4673)
- Robert Sebra (ORCID: https://orcid.org/0000-0001-9267-2426)
- Thenzing J. Silva-Hurtado (ORCID: https://orcid.org/0000-0002-4697-6055)
- Wan Sze Cheng (ORCID: https://orcid.org/0000-0002-1557-0140)
- Gabrielle A. Price (ORCID: https://orcid.org/0000-0001-6054-2395)
- Emine Özen (ORCID: https://orcid.org/0009-0008-4131-4563)
Institutions
- Allen Institute for Brain Science (US)
- MIND Research Institute (US)
- New York Genome Center (US)
- Columbia University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4708
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61