Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects
This study demonstrates that nerve excitability testing can detect pharmacodynamic effects on large myelinated fibers in healthy subjects. Lacosamide statistically significantly reduced peripheral nerve excitability, particularly in large sensory fibers.
Authors
- Caterina Leone (ORCID: https://orcid.org/0000-0002-8828-361X)
- Erik Schnetter
- Irmgard Boesl
- Thomas Li (ORCID: https://orcid.org/0000-0002-4207-4652)
- André Mouraux (ORCID: https://orcid.org/0000-0003-1056-5980)
- Andreas Schilder (ORCID: https://orcid.org/0000-0001-7525-2497)
- Andrea Truini (ORCID: https://orcid.org/0000-0002-2630-7647)
- Karin Schubart (ORCID: https://orcid.org/0000-0002-3364-6575)
- H. W. Pia (ORCID: https://orcid.org/0000-0003-0309-1086)
- Esther Pogatzki‐Zahn (ORCID: https://orcid.org/0000-0003-0981-3940)
- Rolf‐Detlef Treede (ORCID: https://orcid.org/0000-0001-8065-1708)
- Matthias Wittayer
- Irene Tracey (ORCID: https://orcid.org/0000-0003-4134-6115)
- Katy Vincent (ORCID: https://orcid.org/0000-0001-9249-2492)
- Bernd Genser (ORCID: https://orcid.org/0000-0001-5787-0902)
- Nanna Brix Finnerup (ORCID: https://orcid.org/0000-0001-5541-0240)
- Bernhard Pelz
- Ombretta Caspani (ORCID: https://orcid.org/0000-0002-9700-3149)
- Giuseppe Di Pietro (ORCID: https://orcid.org/0000-0002-9645-3578)
- Anna Kostenko
- Hatice Tankişi (ORCID: https://orcid.org/0000-0001-8495-9769)
- Petra Bloms‐Funke
- Zahra Nochi (ORCID: https://orcid.org/0000-0002-8088-1666)
- Marcus Goetz
- Francesca Fardo (ORCID: https://orcid.org/0000-0002-9974-6261)
- Louisien Lebrun (ORCID: https://orcid.org/0000-0002-2459-0354)
- Jan Vollert (ORCID: https://orcid.org/0000-0003-0733-5201)
- Vishvarani Wanigasekera (ORCID: https://orcid.org/0000-0001-9922-8993)
- Rong Chen (ORCID: https://orcid.org/0000-0003-1455-5093)
- Bo Jiang (ORCID: https://orcid.org/0000-0003-3878-515X)
- Sonya C. Chapman (ORCID: https://orcid.org/0000-0002-6453-2749)
- Niko Möller-Grell
Institutions
- European Molecular Biology Organization (DE)
- Optech (Canada) (CA)
- University of Mannheim (DE)
- Aarhus University (DK)
- Heidelberg University (DE)
- University of Exeter (GB)
- Nuffield Orthopaedic Centre (GB)
- University Hospital Heidelberg (DE)
- Aarhus University Hospital (DK)
- University of Oxford (GB)
- Heidelberg University of Education (DE)
- Eli Lilly (United Kingdom) (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Eckert & Ziegler (United States) (US)
- University Hospital Münster (DE)
- Central Institute of Mental Health (DE)
- Bernstein Center for Computational Neuroscience Heidelberg-Mannheim (DE)
- Heidelberg Engineering (Germany) (DE)
- Grünenthal Group (Germany) (DE)
- Teva Pharmaceuticals (United States) (US)
- Danish Pain Research Center (DK)
- University Medical Centre Mannheim (DE)
- Teva Pharmaceuticals (Czechia) (CZ)
- Heidelberg University (US)
- Sapienza University of Rome (IT)
- UCLouvain (BE)
- Grünenthal Group (Germany) (DE)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1097/aln.0000000000005694
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00