Phospholipase A2 from Daboia siamensis venom induces acute kidney injury: involvement of ion channels in an isolated perfused rabbit kidney model
The RvPLA<sub>2</sub> activity requires Ca<sup>2+</sup> for activation which may target distinct sites on the cell membrane, including ion channel receptors in nephrons. The effects of RvPLA<sub>2</sub> on glomerular and renal tubular function are independent and cannot be modified by pretreatment with different ion channel blockers.
Authors
- Narongsak Chaiyabutr (ORCID: https://orcid.org/0000-0002-3207-0885)
- Orawan Khow (ORCID: https://orcid.org/0000-0002-0950-2045)
- Visith Sitprija (ORCID: https://orcid.org/0000-0002-4885-0405)
- Lawan Chanhome (ORCID: https://orcid.org/0000-0003-2425-5000)
- Panithi Laoungbua (ORCID: https://orcid.org/0000-0002-2963-4811)
- Taksa Vasaruchapong (ORCID: https://orcid.org/0000-0001-8197-0356)
Institutions
- Thai Red Cross Society (TH)
- Queen Saovabha Memorial Institute (TH)
Publication Details
- Journal
- The Journal of venomous animals and toxins including tropical diseases
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/1678-9199-jvatitd-2025-0016
- Citations
- 1
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Thailand Research Fund