Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB signaling axis
Our study highlights the crucial role of CXCR4 in deriving T<sub>reg</sub>-mediated immunosuppression via regulating the Rho-GTPase/NF-κB signaling axis, informing the potential of combining CXCR4 blockades with T cell-targeted immunotherapies.
Authors
- Ping Wu (ORCID: https://orcid.org/0000-0001-5718-9922)
- Wencheng Ding (ORCID: https://orcid.org/0009-0004-0881-775X)
- Tian Chu (ORCID: https://orcid.org/0000-0002-6840-0452)
- Yashi Xu
- Miaochun Xu (ORCID: https://orcid.org/0000-0002-9023-1755)
- Shitong Lin (ORCID: https://orcid.org/0000-0002-0737-2785)
- Canhui Cao (ORCID: https://orcid.org/0000-0002-7328-0264)
- Xiaojie Liu (ORCID: https://orcid.org/0000-0001-9843-1674)
- Shiyi Liu (ORCID: https://orcid.org/0000-0001-6139-8380)
- Ting Peng (ORCID: https://orcid.org/0000-0003-3464-0519)
- Li Li
- Peng Wu
- Bai Hu
- Ding Ma (ORCID: https://orcid.org/0000-0002-3341-2998)
Institutions
- Union Hospital (HK)
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13073-025-01515-8
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Tongji University
- Servier