Visualizations of autoregulatory insults in moderate-to-severe paediatric traumatic brain injury: a secondary analysis from the multicentre STARSHIP trial
This novel study visualized the safe and dangerous intervals for PRx and CPPopt as well as the interaction effect between the autoregulatory status and ICP, CPP, and ΔCPPopt in relation to outcome in paediatric TBI. Future prospective trials are needed to evaluate the safety, feasibility, and efficacy of PRx/CPPopt guided management.
Authors
- Collette Spencer
- Robert W Aldridge (ORCID: https://orcid.org/0000-0003-0542-0816)
- Avishay Sarfatti
- Rebecca Beckley
- Anna Maw (ORCID: https://orcid.org/0000-0002-2829-7331)
- Claudia Ann Smith (ORCID: https://orcid.org/0000-0003-3643-6191)
- Ruth Morgan (ORCID: https://orcid.org/0000-0003-1117-2273)
- Esther Daubney (ORCID: https://orcid.org/0000-0003-1206-0169)
- Dusan Raffaj
- Simona Lampariello
- Santosh Sundararajan
- Claire Jennings
- Erta Beqiri (ORCID: https://orcid.org/0000-0002-8108-0000)
- Anders Hånell (ORCID: https://orcid.org/0000-0001-9369-3886)
- Hari Krishnan Kanthimathinathan (ORCID: https://orcid.org/0000-0001-5170-1534)
- Teodor Svedung Wettervik (ORCID: https://orcid.org/0000-0002-4556-5721)
- Holly Belfield
- C. Oxford
- Anoop Mistry
- Toslima Khatun
- Lara Bunni
- Laura Anderson
- Deborah White
- M.-C. Quinton
- Nazima Pathan (ORCID: https://orcid.org/0000-0002-9447-4252)
- Riaz Kayani
- Suzanna Watson (ORCID: https://orcid.org/0000-0002-9225-8919)
- Hafiza Khatun
- Peter J. Hutchinson (ORCID: https://orcid.org/0000-0002-2796-1835)
- Jenny Pond
- Gayathri Subramanian (ORCID: https://orcid.org/0000-0003-0500-6957)
- Julie Morcombe
- Roddy O’Donnell
- Shruti Agrawal (ORCID: https://orcid.org/0000-0001-8695-1314)
- Emily Morgan (ORCID: https://orcid.org/0000-0002-6594-354X)
- Jessica Cutler
- Carly Tooke
- Stefan Yu Bögli (ORCID: https://orcid.org/0000-0001-5386-0811)
- Harish Bangalore
- Anton Mayer
- Marek Czosnyka (ORCID: https://orcid.org/0000-0003-2446-8006)
- Catherine Postlethwaite
- Michał M. Placek (ORCID: https://orcid.org/0000-0001-7936-5202)
- Adam M. H. Young
- Melanie James
- Matthew Garnett
- Peter Smielewski (ORCID: https://orcid.org/0000-0001-5096-3938)
- Oliver Ross
- Caroline Payne
- Stefan Yu B”gli
- Olivia Nugent
- Manuel Cabaleira
Institutions
- Uppsala University (SE)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Bridge University (SS)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13054-025-05568-4
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Uppsala Universitet