Beyond blood-brain barrier disruption and molecular weight: compartmental kinetics of S100B and NSE for neurological prognostication after cardiac arrest
Serum NSE levels closely reflect the degree of BBB disruption and CSF levels, while S100B exhibits a transient early-phase profile, with decreased serum detectability over time, even in the presence of sustained CSF elevation or severe BBB disruption. These findings highlight the importance of interpreting biomarker kinetics across compartments and timepoints rather than relying on molecular weight or BBB status alone.
Authors
- Changshin Kang (ORCID: https://orcid.org/0000-0001-8848-5062)
- Byung Kook Lee (ORCID: https://orcid.org/0000-0003-3571-9448)
- Wonjoon Jeong (ORCID: https://orcid.org/0000-0002-6320-230X)
- Hyewon Ryu (ORCID: https://orcid.org/0000-0001-9313-9930)
- Soyoung Jeon (ORCID: https://orcid.org/0000-0002-9916-1917)
- Ji‐Young Choi (ORCID: https://orcid.org/0000-0002-9774-3665)
- Yenho You
- Jung Soo Park (ORCID: https://orcid.org/0000-0002-4283-5423)
- Ju‐Hong Min (ORCID: https://orcid.org/0000-0002-7338-9067)
Institutions
- Chungnam National University (KR)
- Chonnam National University Hospital (KR)
- Chungnam National University Hospital (KR)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13054-025-05572-8
- Citations
- 5
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 11.27
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea