Relationship between AQP5 and chemotherapy resistance in colorectal cancer cells and its mechanism
Overexpression of AQP5 can promote the growth of colorectal cancer cells and promote the occurrence of drug resistance, which may be related to NF-κB signaling pathway. AQP5-mediated chemoresistance suggests its potential as a target for RNA-based gene silencing therapies.
Authors
- Tong-Fa Ju (ORCID: https://orcid.org/0000-0001-5862-7859)
- Xinchun Liu
- Qi Xie (ORCID: https://orcid.org/0000-0003-2177-7348)
- Chunhua Zhou (ORCID: https://orcid.org/0000-0002-8555-4189)
- Xiaoyun Yang
- Wencheng Kong
Institutions
- Zhejiang Chinese Medical University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1007/s12672-025-03193-9
- Citations
- 1
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81