ZNF385B as a potential prognostic and immunotherapy biomarker in ovarian cancer: insights from pan-cancer analysis

Although ZNF385B, a member of the zinc finger protein family, plays important roles in various physiological processes, its involvement in cancer remains poorly understood. In this study, we systematically investigated the expression patterns, prognostic value, and molecular characteristics of ZNF385B across multiple cancer types using data from The Cancer Genome Atlas (TCGA), with a particular focus on ovarian cancer. To support the bioinformatics findings, a series of functional experiments were performed to explore the biological role of ZNF385B. Our analysis revealed that ZNF385B exhibits differential expression across various cancers and is associated with either favorable or unfavorable prognosis depending on the tumor type. Functional enrichment analyses suggest that ZNF385B is involved in critical cellular processes, such as transcriptional regulation, protein modification, and cellular localization. Separately, ZNF385B expression shows a significant correlation with immune cell infiltration in multiple tumor types, implying a potential role in tumor immune modulation and cancer prognosis. These findings provide novel insights into the biological functions of ZNF385B and highlight its potential as a prognostic and immunological biomarker in ovarian and other cancers.