Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock

Low LDL-C clearance explains the causal association between high genetically predicted pre-infection LDL-C levels and increased septic shock mortality. PCSK9 , ApoB , and ApoE variants were identified as causal, all related to the LDL receptor or its interaction with LDL-C. Enhancing LDL receptor-mediated clearance of pathogen lipid toxins may improve septic shock outcomes.

Authors

Keith R. Walley (ORCID: https://orcid.org/0000-0003-4232-7266)
Nozomi Takahashi (ORCID: https://orcid.org/0000-0001-9417-2396)
Kyle R. Campbell (ORCID: https://orcid.org/0000-0003-2980-3280)
Taka‐aki Nakada (ORCID: https://orcid.org/0000-0002-4480-556X)

Institutions

University of British Columbia (CA)
Chiba University (JP)
St. Paul's Hospital (CA)

Publication Details

Journal: Critical Care Medicine
Published: 2025-08-04
DOI: https://doi.org/10.1097/ccm.0000000000006809
Citations: 1
Primary Topic: Sepsis Diagnosis and Treatment
Type: article
Field-Weighted Citation Impact: 1.35

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article

Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock

Keith R. Walley, Nozomi Takahashi, Kyle R. Campbell, Taka‐aki Nakada

Aug 4, 2025

1 citations

Critical Care Medicine

Sepsis Diagnosis and Treatment

1.35

article

Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock

Keith R. Walley, Nozomi Takahashi, Kyle R. Campbell, Taka‐aki Nakada

August 4, 2025article en

1 citations

Abstract

Low LDL-C clearance explains the causal association between high genetically predicted pre-infection LDL-C levels and increased septic shock mortality. PCSK9 , ApoB , and ApoE variants were identified as causal, all related to the LDL receptor or its interaction with LDL-C. Enhancing LDL receptor-mediated clearance of pathogen lipid toxins may improve septic shock outcomes.

Critical Care MedicineVol. 53(10)

University of British Columbia (CA), Chiba University (JP), St. Paul's Hospital (CA)

Good health and well-being

Openalex Percentile: Top 17%

Sepsis Diagnosis and Treatment

1.35

DOI Source OpenAlex

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Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock — Keith R. Walley, Nozomi Takahashi, et al. · Critical Care Medicine (2025) | TGRS Research Map | TGRS