An IV Sodium Bicarbonate Shortage in the Critically Ill: An Interrupted Time-Series Analysis
Emergency conservation measures that accompanied a worldwide shortage of IV sodium bicarbonate were associated with a reduction in IV sodium bicarbonate use among critically ill patients with acidemia. This was not linked to changes in survival or length of stay outcomes. Future bicarbonate research should focus on subgroups such as those with severe acidemia and/or advanced renal insufficiency.
Authors
- Danny J. Zuege (ORCID: https://orcid.org/0000-0003-2033-5847)
- Sean M. Bagshaw (ORCID: https://orcid.org/0000-0003-3633-6596)
- Henry T. Stelfox (ORCID: https://orcid.org/0000-0003-1231-1490)
- Amanda Y. Leong (ORCID: https://orcid.org/0000-0002-2593-7911)
- Hannah Wunsch (ORCID: https://orcid.org/0000-0001-5477-8422)
- Andrea Soo (ORCID: https://orcid.org/0000-0002-5373-7239)
- Andrew Bond (ORCID: https://orcid.org/0000-0002-4255-4488)
- Daniel J. Niven
Institutions
- Alberta Health Services (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- Cornell University (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1097/ccm.0000000000006813
- Citations
- 3
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 4.29