Toxoplasma gondii-induced host’s high secretion of 25-hydroxycholesterol for immunoprotection
Our study demonstrated that T. gondii infection activates the CH25H-25-HC axis to induce microglial M1 polarization and cytokine secretion, thereby establishing an anti-Toxoplasma defense. These findings highlight the central role of cholesterol metabolism in T. gondii pathogenesis and provide innovative strategies for the diagnosis, prevention, and treatment of toxoplasmosis.
Authors
- Hong‐Juan Peng (ORCID: https://orcid.org/0000-0002-9345-8218)
- Zihan Yang (ORCID: https://orcid.org/0000-0003-4305-049X)
- Chi Zhang (ORCID: https://orcid.org/0000-0002-6350-4906)
- Jiajia Zheng (ORCID: https://orcid.org/0000-0003-3939-9875)
- Yingying Lu (ORCID: https://orcid.org/0000-0002-7187-1511)
- Weiling Wu
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s13071-025-06890-0
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province