Preclinical evaluation of candidate “kill or cure” strategies to treat MFN2-related lipodystrophy
Ethanol mildly exacerbates murine MFN2-related MSL, while rapamycin is tolerated. MFN2-related MSL may not be solely attributable to compromised oxidative phosphorylation.
Authors
- Jana Buchan
- David B. Savage (ORCID: https://orcid.org/0000-0002-7857-7032)
- Jake P. Mann (ORCID: https://orcid.org/0000-0002-4711-9215)
- Ineke Luijten (ORCID: https://orcid.org/0000-0001-5768-275X)
- Eleanor J. McKay (ORCID: https://orcid.org/0000-0002-5690-6042)
- Robert K. Semple (ORCID: https://orcid.org/0000-0001-6539-3069)
- Xiong Weng (ORCID: https://orcid.org/0009-0000-1598-7475)
- Ami Onishi
- Ula Kibildyte
Institutions
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- University of Birmingham (GB)
- University of Lausanne (CH)
- University of Edinburgh (GB)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1186/s10020-025-01314-2
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Vetenskapsrådet
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre