Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression
In this cross-sectional study of 309 adults with depression, 4 latent profiles were identified. Default mode network hypoconnectivity defined profile 4, supporting its role as a key neural indicator of antidepressant response. CM was associated with both the highest and lowest remission rates, indicating it does not uniformly project negative outcomes and suggesting that neurobiological resilience in the context of childhood trauma may have contributed to more favorable clinical outcomes; further research is needed to refine clinical applications.
Authors
- Jessica Rowe (ORCID: https://orcid.org/0000-0002-6622-1047)
- Katharine Dunlop (ORCID: https://orcid.org/0000-0003-4366-7692)
- Susan Rotzinger (ORCID: https://orcid.org/0000-0003-1980-3674)
- Jane Allyson Foster (ORCID: https://orcid.org/0000-0002-8579-4705)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Scott Squires (ORCID: https://orcid.org/0000-0002-8213-9772)
- Rudolf Uher (ORCID: https://orcid.org/0000-0002-2998-0546)
- Roumen Milev (ORCID: https://orcid.org/0000-0001-6884-171X)
- Sidney H. Kennedy (ORCID: https://orcid.org/0000-0001-5339-7185)
- Raegan Mazurka (ORCID: https://orcid.org/0000-0002-4974-4815)
- Nikita Nogovitsyn (ORCID: https://orcid.org/0000-0001-5445-1841)
- Mojdeh Zamyadi (ORCID: https://orcid.org/0000-0002-8455-0784)
- Jordan Poppenk (ORCID: https://orcid.org/0000-0002-3315-5098)
- Benicio Noronha Frey (ORCID: https://orcid.org/0000-0001-8267-943X)
- Stefanie Hassel (ORCID: https://orcid.org/0000-0001-7240-1581)
- Kate Leslie Harkness (ORCID: https://orcid.org/0000-0002-0319-8994)
- Raymond W. Lam (ORCID: https://orcid.org/0000-0001-7142-4669)
Institutions
- St. Michael's Hospital (CA)
- Dalhousie University (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Baycrest Hospital (CA)
- Southwestern Medical Center (US)
- Indoc Research (CA)
- Hotchkiss Brain Institute (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- The University of Texas Southwestern Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.25147
- Citations
- 1
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 1.39