Early Treatment With Intravenous Immunoglobulins and Outcomes of Patients With Anti-IgLON5 Disease
In this study, early initiation of intravenous immunoglobulins (within the first year of onset) was associated with favorable long-term outcomes and improved survival in anti-IgLON5 disease. Larger prospective studies are needed to validate this finding.
Authors
- Hauke Schneider (ORCID: https://orcid.org/0000-0002-9641-0922)
- Morten Blaabjerg (ORCID: https://orcid.org/0000-0001-6007-1861)
- Walid Fazeli (ORCID: https://orcid.org/0000-0002-9425-5535)
- Henrik Rohner
- Jan Lewerenz (ORCID: https://orcid.org/0000-0002-9272-529X)
- Simon Schuster (ORCID: https://orcid.org/0000-0001-6038-0138)
- Lucie de Azevedo
- Olga Simova
- Christian Hofmann (ORCID: https://orcid.org/0000-0002-1703-4800)
- Marina Flotats‐Bastardas (ORCID: https://orcid.org/0000-0001-7696-4808)
- Sonka Benesch
- Rolf Kern
- Philip Hillebrand
- Sebastian Baatz
- Ingo Kleiter (ORCID: https://orcid.org/0000-0002-8249-4408)
- Felix Fischbach
- Marie Madlener (ORCID: https://orcid.org/0000-0002-6299-8238)
- Claudia Sommer (ORCID: https://orcid.org/0000-0002-7064-5002)
- Robert Markewitz
- Brigitte Wildemann (ORCID: https://orcid.org/0000-0002-5389-3338)
- Caroline Giordana
- Martin Lesser (ORCID: https://orcid.org/0000-0002-0318-5739)
- Makbule Şenel (ORCID: https://orcid.org/0000-0002-2737-7495)
- Felix von Podewils (ORCID: https://orcid.org/0000-0002-3134-8697)
- Simone Zittel (ORCID: https://orcid.org/0000-0002-3767-6376)
- Max Kaufmann (ORCID: https://orcid.org/0000-0002-1954-4425)
- Hagen B. Huttner (ORCID: https://orcid.org/0000-0002-0992-8871)
- Francesc Graus (ORCID: https://orcid.org/0000-0002-8924-8322)
- Constanze Kerin
- Jost Obrocki
- Manuel Alexander Friese (ORCID: https://orcid.org/0000-0001-6380-2420)
- Jan D. Lünemann (ORCID: https://orcid.org/0000-0002-3007-708X)
- Lúcio Huebra Pimentel Filho (ORCID: https://orcid.org/0000-0002-1543-0711)
- Luise Appeltshauser (ORCID: https://orcid.org/0000-0001-5248-4009)
- Michael Nagel (ORCID: https://orcid.org/0000-0001-8436-8643)
- Susanne Knake (ORCID: https://orcid.org/0000-0002-6298-0513)
- Inmaculada Puertas (ORCID: https://orcid.org/0000-0002-9567-1274)
- Caspar Seitz (ORCID: https://orcid.org/0000-0002-3086-9730)
- Agnita J.W. Boon (ORCID: https://orcid.org/0000-0002-5042-2792)
- Sigrid Reuter
- Johannes Piepgras
- Sarah Bernsen (ORCID: https://orcid.org/0000-0001-7485-2626)
- Achim Berthele (ORCID: https://orcid.org/0000-0001-9650-6222)
- Yavor Yalachkov (ORCID: https://orcid.org/0000-0002-0805-771X)
- Birgit Berger
- Sandra Stanković (ORCID: https://orcid.org/0000-0003-3114-0869)
- Katharina Eisenhut (ORCID: https://orcid.org/0000-0001-6448-3126)
- Simone C. Tauber (ORCID: https://orcid.org/0000-0001-9149-3071)
- Frank Leypoldt (ORCID: https://orcid.org/0000-0002-8972-515X)
- Lídia Sabater (ORCID: https://orcid.org/0000-0001-8556-6166)
- Timo Deba
- Fabian Möller (ORCID: https://orcid.org/0000-0001-6877-8327)
- Hayrettin Tumani (ORCID: https://orcid.org/0000-0002-1647-6201)
- Annette Baumgärtner
- Annika Kather
- Sonia Quintas (ORCID: https://orcid.org/0000-0003-0622-8228)
- Christian Urbanek
- Juan Carlos García‐Moncó (ORCID: https://orcid.org/0000-0003-2556-1288)
- Mathias Fousse (ORCID: https://orcid.org/0000-0001-5489-1492)
- Carlos Martínez Quesada (ORCID: https://orcid.org/0000-0002-2213-7767)
- Martin Häusler (ORCID: https://orcid.org/0000-0002-8433-8919)
- Regina Trollmann (ORCID: https://orcid.org/0000-0001-6031-8537)
- Silke Tonner
- Gernot Reimann (ORCID: https://orcid.org/0000-0001-7019-6975)
- Peter Huppke (ORCID: https://orcid.org/0009-0004-1183-4905)
- María Elena Erro (ORCID: https://orcid.org/0000-0002-9707-4190)
- Markus Rauchenzauner
- Tobias Freilinger
- Chen Fei Ng (ORCID: https://orcid.org/0000-0003-2540-9905)
- Niels Hansen (ORCID: https://orcid.org/0000-0001-5785-9594)
- Inga Koneczny (ORCID: https://orcid.org/0000-0002-0567-021X)
- Felix Rosenow (ORCID: https://orcid.org/0000-0002-3989-7471)
- Aiden Haghikia (ORCID: https://orcid.org/0000-0001-9629-3298)
- Anna Heidbreder (ORCID: https://orcid.org/0000-0002-9552-7619)
- Johanna Maria Helena Rau (ORCID: https://orcid.org/0000-0002-5186-3338)
- Michael Karenfort (ORCID: https://orcid.org/0000-0002-8925-3543)
- Harald Prüß (ORCID: https://orcid.org/0000-0002-8283-7976)
- Ulrich Hofstadt‐van Oy (ORCID: https://orcid.org/0000-0003-4956-597X)
- Friedrich Ebinger
- Yvette S. Crijnen (ORCID: https://orcid.org/0000-0003-0279-7140)
- Dietrich Sturm
- Sven Guenther Meuth (ORCID: https://orcid.org/0000-0003-2571-3501)
- Tarsis Farias
- Judith Wagner (ORCID: https://orcid.org/0000-0002-0776-6821)
- Anja Tietz
- Franziska E. Möllers
- Marius Ringelstein (ORCID: https://orcid.org/0000-0003-3618-8407)
- Verena Kraus
- Christos Krogias (ORCID: https://orcid.org/0000-0003-2965-4051)
- Franziska Thaler
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Sergio Castro‐Gomez (ORCID: https://orcid.org/0000-0002-1581-474X)
- Mona Dreesmann
- Christoph Kellinghaus (ORCID: https://orcid.org/0000-0001-5491-2302)
- Yannic Saathoff
- Stefan Bittner (ORCID: https://orcid.org/0000-0003-2179-3655)
- Oliver Bähr (ORCID: https://orcid.org/0000-0003-2073-037X)
- Marina Entscheva
- Lara Zieger
- Niklas Vogel (ORCID: https://orcid.org/0009-0004-1461-2419)
- Mareike Jansen
- Oliver Stammel
- Britta Greshake
- Sigrid Mues
- Daniela Esser
- Kerstin Hellwig (ORCID: https://orcid.org/0000-0003-4467-9011)
- Jens Schmidt (ORCID: https://orcid.org/0000-0002-5589-2371)
- Robert Weissert (ORCID: https://orcid.org/0000-0002-1295-1271)
- Ruth Schilling
- Thomas Grüter (ORCID: https://orcid.org/0000-0001-8927-9818)
- Gian Maria Asioli (ORCID: https://orcid.org/0000-0002-1288-8102)
- Anna Gorsler (ORCID: https://orcid.org/0000-0001-5980-0983)
- Pasquale Nigro (ORCID: https://orcid.org/0000-0002-2736-0095)
- Raphael Ribeiro Spera (ORCID: https://orcid.org/0000-0003-3066-3457)
- Oliver Grauer
- Kurt‐Wolfram Sühs (ORCID: https://orcid.org/0000-0002-8077-481X)
- Kim Kristin Falk (ORCID: https://orcid.org/0000-0002-3573-9257)
- Astrid Blaschek (ORCID: https://orcid.org/0000-0003-2918-0159)
- Steffen Pfeuffer (ORCID: https://orcid.org/0000-0001-5171-4845)
- Jan Wagner (ORCID: https://orcid.org/0000-0002-0459-8885)
- Fedor Heidenreich
- Karsten Witt (ORCID: https://orcid.org/0000-0002-9384-3474)
- Dirk Fitzner (ORCID: https://orcid.org/0000-0002-2511-6216)
- Joachim Havla (ORCID: https://orcid.org/0000-0002-4386-1340)
- Raphael Reinecke (ORCID: https://orcid.org/0000-0001-8852-7234)
- Kevin M. Rostasy (ORCID: https://orcid.org/0000-0002-2180-5321)
- Karl‐Christian Thies (ORCID: https://orcid.org/0000-0001-9939-4166)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Raphaela Heusgen
- Maarten J. Titulaer (ORCID: https://orcid.org/0000-0002-1033-3840)
- Sascha Berning (ORCID: https://orcid.org/0009-0000-6264-2824)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Michael P. Malter (ORCID: https://orcid.org/0000-0003-2535-4553)
- Andre Dik (ORCID: https://orcid.org/0000-0003-4695-4136)
- Suzanne C. Franken (ORCID: https://orcid.org/0009-0006-7582-5295)
- Juna M. de Vries
- Alexander Emmer (ORCID: https://orcid.org/0000-0003-4272-8887)
- Michelle Braun
- Josep Dalmau (ORCID: https://orcid.org/0000-0001-5856-2813)
- Henning Stolze
- Thomas Schmitter
- Juliane Spiegler (ORCID: https://orcid.org/0000-0002-1737-0628)
- Corinna Trebst
- Catharina C. Groß (ORCID: https://orcid.org/0000-0002-4872-9189)
- Kathrin Doppler (ORCID: https://orcid.org/0000-0003-2883-0009)
- Aleksandra Juranek
- Ralf Gold (ORCID: https://orcid.org/0000-0002-7223-3052)
- Antonio Martín‐Bastida (ORCID: https://orcid.org/0000-0002-8480-7009)
- Paweł Tacik (ORCID: https://orcid.org/0000-0002-4234-5635)
- Robert L. Berger
- Kai Siebenbrodt (ORCID: https://orcid.org/0000-0003-3827-4245)
- Laura Ehrhardt
- Carolin Baade‐Büttner (ORCID: https://orcid.org/0009-0000-3098-5961)
- Alexandra Philipsen (ORCID: https://orcid.org/0000-0001-6876-518X)
- Mirjam Korporal‐Kuhnke (ORCID: https://orcid.org/0000-0001-8070-7142)
- Stjepana Kovac (ORCID: https://orcid.org/0000-0002-2500-6893)
- Martin Berghoff (ORCID: https://orcid.org/0000-0001-7954-3646)
- Thomas Pfefferkorn (ORCID: https://orcid.org/0000-0002-7072-0295)
- Maja Patalong‐Ogiewa
- Nico Melzer (ORCID: https://orcid.org/0000-0002-2420-701X)
- Thorleif Etgen (ORCID: https://orcid.org/0000-0002-7857-6435)
- Christine Strippel (ORCID: https://orcid.org/0000-0002-7080-6769)
- Robert Rehmann (ORCID: https://orcid.org/0000-0003-1429-4399)
- Valentin Held
- Peter Körtvélyessy (ORCID: https://orcid.org/0000-0001-9990-2458)
- Justina Dargvainiene (ORCID: https://orcid.org/0009-0002-4114-3748)
- Robert Handreka
- Thilo van Eimeren (ORCID: https://orcid.org/0000-0002-6951-2325)
- Javier Villacieros‐Álvarez (ORCID: https://orcid.org/0000-0002-5443-1434)
- Marie‐Luise Mono (ORCID: https://orcid.org/0000-0003-4886-0010)
- Loana Penner (ORCID: https://orcid.org/0009-0000-4250-0087)
- Jens Schaumberg
- Fatme Seval Ismail (ORCID: https://orcid.org/0000-0003-3930-8056)
- Christian G. Bien (ORCID: https://orcid.org/0000-0003-2225-8654)
- Thanos Tsaktanis
- Romana Höftberger (ORCID: https://orcid.org/0000-0002-5769-1100)
- Katya Kotschet
- Federica Provini (ORCID: https://orcid.org/0000-0001-9063-2658)
- Bettina Balint (ORCID: https://orcid.org/0000-0003-4127-8554)
- Norbert Brüggemann (ORCID: https://orcid.org/0000-0001-5969-6899)
- Gerd Meyer zu Hörste (ORCID: https://orcid.org/0000-0002-4341-4719)
- Florian Then Bergh (ORCID: https://orcid.org/0000-0001-8604-8408)
- Carsten Finke (ORCID: https://orcid.org/0000-0002-7665-1171)
- Lena Kristina Pfeffer (ORCID: https://orcid.org/0000-0003-3057-6492)
- Ina Reichen
- Christoph Lehrich
- Milene Schmitz
- Jannis Justus Maaß
- Ángela Milán-Tomás (ORCID: https://orcid.org/0000-0001-8729-2613)
- Josef Schill
- Franz Blaes (ORCID: https://orcid.org/0000-0002-8628-095X)
- Carlos Ordás (ORCID: https://orcid.org/0000-0003-3551-8769)
- Nils G. Margraf (ORCID: https://orcid.org/0000-0003-2197-1079)
- Patrick Schramm (ORCID: https://orcid.org/0000-0001-5158-6708)
- Daniel Rapp (ORCID: https://orcid.org/0000-0003-0453-7318)
- Sven Jarius (ORCID: https://orcid.org/0000-0003-4849-2545)
- Ellen Knierim (ORCID: https://orcid.org/0000-0002-4769-7322)
- Sebastian Bauer (ORCID: https://orcid.org/0000-0001-7571-8496)
- Dominique Endres (ORCID: https://orcid.org/0000-0001-7322-1195)
- Til Menge (ORCID: https://orcid.org/0000-0003-3459-8867)
- Andreas van Baalen (ORCID: https://orcid.org/0000-0001-7988-5224)
- Anne‐Katrin Pröbstel (ORCID: https://orcid.org/0000-0002-7748-1872)
- Tanja Kümpfel
- Julian Dominik
- Alexander Finke
- Steffen Syrbe (ORCID: https://orcid.org/0000-0003-2543-4844)
- G Seidel (ORCID: https://orcid.org/0000-0003-2804-7735)
- David J. Pedrosa (ORCID: https://orcid.org/0000-0002-5403-1959)
- Mosche Pompsch (ORCID: https://orcid.org/0009-0005-0493-6409)
- Mateus Mistieri Simabukuro (ORCID: https://orcid.org/0000-0001-9243-3337)
- Michael Adelmann
- Marc Nikolaus (ORCID: https://orcid.org/0000-0002-3678-5159)
- Marlene Tschernatsch (ORCID: https://orcid.org/0000-0003-2725-0811)
- Tobias Baumgartner (ORCID: https://orcid.org/0000-0001-5935-9841)
- Jens Harmel (ORCID: https://orcid.org/0000-0002-0578-5973)
- Nicola Tambasco (ORCID: https://orcid.org/0000-0003-1497-4482)
- Jonathan Wickel (ORCID: https://orcid.org/0000-0002-5854-3759)
- Antonios Bayas (ORCID: https://orcid.org/0000-0002-7418-9040)
- Antonia Harms (ORCID: https://orcid.org/0000-0001-9790-8127)
- Ilya Ayzenberg
- Christian Geis (ORCID: https://orcid.org/0000-0002-9859-581X)
- Muriel Stoppe
- Nele Retzlaff
- Klarissa Hanja Stürner (ORCID: https://orcid.org/0000-0003-2199-3315)
- Theodor Rüber (ORCID: https://orcid.org/0000-0002-6180-7671)
- Robin W. van Steenhoven (ORCID: https://orcid.org/0009-0003-6842-095X)
- Marco Gallus (ORCID: https://orcid.org/0009-0007-4954-8420)
- Ruth Kerkhoff
- Duygu Pul
- Jaqueline Klausewitz (ORCID: https://orcid.org/0009-0009-9880-1191)
- Chung Ha-Yeun
- Andeas Linsa
- Kristin Stefanie Melzer
- Gesa Schreyer
- Methap Türedi
- Max Vogtmann
- Kartharina Wurdack
- Lena Edelhoff
- Yetzenia Dubraska Haro Alizo
- Jesús Jiménez (ORCID: https://orcid.org/0000-0003-0544-7656)
- Mareike Schimmel (ORCID: https://orcid.org/0000-0003-0611-3922)
- Frank Seifert (ORCID: https://orcid.org/0000-0002-7065-2528)
- Stephan J. Rüegg (ORCID: https://orcid.org/0000-0002-5836-622X)
- George Trendelenburg (ORCID: https://orcid.org/0000-0001-9277-6241)
- Thomas Seifert‐Held (ORCID: https://orcid.org/0000-0001-8121-3662)
- Andreas Binder (ORCID: https://orcid.org/0000-0001-7795-1195)
- Carles Gaig
- Armin Grau
- Stefanie Becker (ORCID: https://orcid.org/0000-0001-8503-6368)
- Stephan Schreiber (ORCID: https://orcid.org/0000-0003-4251-6067)
- Frank Hoffmann
- Corinna Bien
- Sharon Veenbergen (ORCID: https://orcid.org/0009-0009-9114-2998)
- Wolfgang Heide
- M. M. Gebhard
- Monika Meister
- Ina Schröder
- Jürgen Faiss
- Alejandro Herrero-San Martín
- Matthias von Mering
- Andrea Kraft (ORCID: https://orcid.org/0009-0001-3748-1798)
- Martina Jansen
- Sven Ehrlich
- Ina-Isabelle Schmütz
- Amelie Bohn
- Karin Storm van’s Gravesande
- Klaus-Peter Wandinger
- Markus Krämer
- Andeas Steinbrecher
- Julia Maren Decker
- Gregor Kuhlenbäumer
- Nieves Téllez
- Felix F. Konen
- Florian Schöberl
- Daniel Bittner (ORCID: https://orcid.org/0000-0001-9867-9274)
- Dominica Hudasch
- Frank Kohlert
- Anna-Katharina Mundorf
- Philip Schwenkenbecher
- Rem Vaizian
- Njiku Melchior Wellmer
- Julia Bierwith
- Johanna-Maria Dietmaier
- Jonas Marius
- Alina Neffgen
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Universität Ulm (DE)
- University of Münster (DE)
- Erasmus MC (NL)
- Universitätsklinikum Erlangen (DE)
- University Hospital Münster (DE)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- University Hospital Schleswig-Holstein (DE)
- Hospital Clínic de Barcelona (ES)
- Navarrabiomed (ES)
- Kepler Universitätsklinikum (AT)
- Katholisches Klinikum Koblenz (DE)
- Klinikum Lippe (DE)
- Jena University Hospital (DE)
- Antea Group (France) (FR)
- St. Josef-Hospital (DE)
- Martha-Maria Hospital (DE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Barcelona School of Economics (ES)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
- Ruhr University Bochum (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1001/jamaneurol.2025.2574
- Citations
- 3
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17