Elezanumab Accelerates Post‐Injury Regeneration of Olfactory Sensory Neurons in a Methimazole‐Induced Mouse Model
Elezanumab accelerates olfactory sensory neuron regeneration in a methimazole-induced mouse model. Repulsive guidance molecule A blockade increases GAP43<sup>+</sup> and OMP<sup>+</sup> cells dorsally while sparing basal cells. This approach offers a novel therapy for sensorineural olfactory disorder.
Authors
- Kenji Kondo (ORCID: https://orcid.org/0000-0002-0496-5067)
- Eri Mori (ORCID: https://orcid.org/0000-0003-3273-3789)
- Nobuyoshi Otori (ORCID: https://orcid.org/0000-0001-5917-5452)
- Hironobu Nishijima (ORCID: https://orcid.org/0000-0001-9056-9900)
- Rumi Ueha (ORCID: https://orcid.org/0000-0002-0608-7237)
- Hirotaka Tanaka (ORCID: https://orcid.org/0000-0002-5322-5479)
- Masayoshi Kobayashi (ORCID: https://orcid.org/0000-0001-5830-1509)
Institutions
- Jikei University School of Medicine (JP)
- Mie University (JP)
- University of Tokyo Hospital (JP)
- Kyorin University Hospital (JP)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1002/alr.70013
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- Japan Society for the Promotion of Science