Novel Gel Techniques for Meloxicam Transdermal Administration as Topical Gel: A Systematic Review

A potential non-steroidal anti-inflammatory medication (NSAID) for the prevention and treatment of both acute and chronic pain is meloxicam. Meloxicam has limited therapeutic application because of its weak water solubility. Furthermore, it is challenging to develop a suitable NSAID-based delivery system that can pass through the skin barrier for transdermal treatments due to the skin's impermeability. Developed as transdermal drug delivery systems, hydrophilic/hydrophobic gels can significantly enhance other drug administration methods (such oral or intravenous) while preventing or reducing negative effects. This study's main goal was to highlight several gel formulations with improved qualities that may be applied to the long-term administration of meloxicam in a minimally invasive way.